Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport.

@article{Pfeiffer2011CaenorhabditisEU,
  title={Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport.},
  author={Matthew Pfeiffer and Ernst-Bernhard Kayzer and Xianmei Yang and Ellen J. Abramson and M Alexander Kenaston and Cory U. Lago and H Z Lo and Margaret M Sedensky and Adam L. Lunceford and Catherine F. Clarke and S. Jinhui Wu and Chris Mcleod and Toren Finkel and Philip G Morgan and Edward M. Mills},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 43},
  pages={37712-20}
}
The novel uncoupling proteins (UCP2-5) are implicated in the mitochondrial control of oxidant production, insulin signaling, and aging. Attempts to understand their functions have been complicated by overlapping expression patterns in most organisms. Caenorhabditis elegans nematodes are unique because they express only one UCP ortholog, ceUCP4 (ucp4). Here, we performed detailed metabolic analyzes in genetically modified nematodes to define the function of the ceUCP4. The knock-out mutant ucp4… CONTINUE READING
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ceUCP4 Powers Complex II 37720 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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