Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes

  • Timothy Lovelessa, Hiroshi Qadotab, +1 author Jeff Hardina
We have identified and characterized sorb-1, the only sorbin and SH3 domain– containing protein family member in Caenorhabditis elegans. SORB-1 is strongly localized to integrin adhesion complexes in larvae and adults, including adhesion plaques and dense bodies (Z-disks) of striated muscles and attachment plaques of smooth muscles. SORB-1 is recruited to… CONTINUE READING