Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator

@article{Li2008CaenorhabditisEH,
  title={Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator},
  author={Ji Li and Atsushi Ebata and Yuqing Dong and Gizem Rizki and Terri Naoko Iwata and Siu Sylvia Lee},
  journal={PLoS Biology},
  year={2008},
  volume={6},
  pages={1565 - 1571}
}
The transcription factor DAF-16/forkhead box O (FOXO) is a critical longevity determinant in diverse organisms, however the molecular basis of how its transcriptional activity is regulated remains largely unknown. We report that the Caenorhabditis elegans homolog of host cell factor 1 (HCF-1) represents a new longevity modulator and functions as a negative regulator of DAF-16. In C. elegans, hcf-1 inactivation caused a daf-16-dependent lifespan extension of up to 40% and heightened resistance… CONTINUE READING

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