Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.

  title={Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.},
  author={Christian E Rocheleau and Agneta R{\"o}nnlund and Simon Tuck and Meera V Sundaram},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 33},
Connector enhancer of Ksr (CNK) is a conserved multidomain protein essential for Ras signaling in Drosophila melanogaster and thought to be involved in Raf kinase activation. However, the precise role of CNK in Ras signaling is not known, and mammalian CNKs are proposed to have distinct functions. Caenorhabditis elegans has a single CNK homologue, cnk-1. Here, we describe the role of cnk-1 in C. elegans Ras signaling and its requirements for LIN-45 Raf activation. We find that cnk-1 positively… CONTINUE READING

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