Caenorhabditis Elegans Mutants Predict Regulation of Fatty Acids and Endocannabinoids by the CYP-35A Gene Family

@article{Aarnio2011CaenorhabditisEM,
  title={Caenorhabditis Elegans Mutants Predict Regulation of Fatty Acids and Endocannabinoids by the CYP-35A Gene Family},
  author={Vuokko Aarnio and M. Lehtonen and M. Storvik and J. Callaway and M. Lakso and G. Wong},
  journal={Frontiers in Pharmacology},
  year={2011},
  volume={2}
}
Background: Cytochrome P450s (CYPs) are mono-oxygenases that metabolize endogenous compounds, such as fatty acids and lipid signaling molecules, and furthermore have a role in metabolism of xenobiotics. In order to investigate the role of CYP genes in fat metabolism at the molecular level, four Caenorhabditis elegans mutants lacking functional CYP-35A1, CYP-35A2, CYP-35A4, and CYP-35A5 were characterized. Relative amounts of fatty acids, as well as endocannabinoids, which regulate weight gain… Expand
Application of Mass Spectrometry in Unravelling the Secrets of the Endocannabinoid System
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