Cadmium reduces nitric oxide production by impairing phosphorylation of endothelial nitric oxide synthase.

  title={Cadmium reduces nitric oxide production by impairing phosphorylation of endothelial nitric oxide synthase.},
  author={Syamantak Majumder and Ajit Muley and Gopi Krishna Kolluru and Samir Saurabh and Kuppusamy Palaniappan Tamilarasan and Sidhharth Chandrasekhar and Hima Bindu Reddy and Sharad Purohit and Suvro Chatterjee},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  volume={86 1},
Cadmium (Cd) perturbs vascular health and interferes with endothelial function. However, the effects of exposing endothelial cells to low doses of Cd on the production of nitric oxide (NO) are largely unknown. The objective of the present study was to evaluate these effects by using low levels of CdCl2 concentrations, ranging from 10 to 1000 nmol/L. Cd perturbations in endothelial function were studied by employing wound-healing and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium… CONTINUE READING


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