Cadmium nephrotoxicity and evacuation from the body in a rat modeled subchronic intoxication.

@article{Aoyagi2003CadmiumNA,
  title={Cadmium nephrotoxicity and evacuation from the body in a rat modeled subchronic intoxication.},
  author={Teiichiro Aoyagi and Kunihiro Hayakawa and Keisuke Miyaji and Hiromichi Ishikawa and Makoto Hata},
  journal={International journal of urology : official journal of the Japanese Urological Association},
  year={2003},
  volume={10 6},
  pages={332-8}
}
BACKGROUND Cadmium (Cd) is an important industrial pollutant, although its mechanism of toxicity has not been completely clarified. We studied Cd-induced subchronic nephrotoxicity and the cadmium evacuation system in rats and cultured human renal tubular cells. METHODS Male Sprague-Dawley rats were subcutaneously injected with 0.6 mg Cd/kg per day for periods of 3, 5 and 8 weeks. The concentration of Cd in urine, serum and kidneys was measured by atomic absorption spectrophotometry… CONTINUE READING

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