Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid in the mouse.

@article{Jones1992CadmiumMI,
  title={Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid in the mouse.},
  author={M. M. Jones and P. K. Singh and Glen R. Gale and Amos B. Smith and Loretta M. Atkins},
  journal={Pharmacology \& toxicology},
  year={1992},
  volume={70 5 Pt 1},
  pages={
          336-43
        }
}
The relative activities of a series of nine monoalkyl esters of meso-2,3-dimercaptosuccinic acid have been examined as agents for the mobilization of cadmium from mice one week after intraperitoneal administration of cadmium chloride. Eight of these are newly synthetized; all are of the type ROOCCH(SH)CH(SH)COOH, were R = Me, MMDMS; R = C2H5, MEDMS; R = (CH2)2CH3, Mn-PDMS; R = CHMe2, Mi-PDMS; R = (CH2)3CH3, Mn-BDMS; R = CH2CHMe2, Mi-BDMS; R = (CH2)4CH3, Mn-ADMS; R = (CH2)2CHMe2, Mi-ADMS; and R… Expand
Cadmium mobilization by monoaralkyl- and monoalkyl esters of meso-2,3-dimercaptosuccinic acid and by a dithiocarbamate.
TLDR
The manner in which the later injections removed smaller fractions of the total body cadmium is consistent with a bodily distribution of these compounds by which they are concentrated primarily in the kidneys and the liver, with much smaller amounts reaching other organs. Expand
Mobilization of lead in mice by administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid.
TLDR
It is suggested that the ability of these monoesters to cross cell membranes may account for their superiority to DMSA in mobilizing brain lead in this animal model. Expand
Effect of chelators, monoisoamyl meso-2,3-dimercaptosuccinate and N-(4-methylbenzyl)-4-O-(beta-D-galactopyranosyl)-D-glucamine-N-carbodit hioate, on cadmium and essential element levels in mice.
TLDR
Both compounds were able to correct the changes in the level of essential elements caused by cadmium, and on an equimolar basis MeBLDTC was superior to Mi-ADMS. Expand
Prolonged oral treatment with two monoesters of meso-2,3-dimercaptosuccinic acid for depleting inorganic mercury retention in suckling rats.
TLDR
Monoesters of DMSA were superior to DMSA in decreasing body and organ Hg retention and the reductions in the whole body and organs were significantly greater than in controls or DMSA-treated rats. Expand
Decreasing 203Hg retention by intraperitoneal treatment with monoalkyl esters of meso‐2,3‐dimercaptosuccinic acid in rats
TLDR
The effect of nine monoalkyl esters of meso‐2,3‐dimercaptosuccinic acid (DMSA) on 203Hg retention after a single i.p. dose was evaluated in 6–7 week‐old female albino rats, with a significantly lower body burden of mercury than the controls. Expand
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TLDR
The major finding is that Mi-ADMS at low doses causes a much higher reduction in brain retention of lead in sucklings than DMSA, important because the brain is considered to be the target organ of lead toxicity in the youngest age group. Expand
Therapeutic potential of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats.
TLDR
The dose dependent effects of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid to offset the characteristic biochemical, immunological, oxidative stress consequences and DNA damage following sub-chronic administration of Gallium arsenide and the mobilization of gallium and arsenic were examined. Expand
meso-2,3-dimercaptosuccinic acid monoalkyl esters: effects on mercury levels in mice.
TLDR
Determination of the comparative dose-response relationships of DMSA and Mi-ADMS on corporal and renal mercury concentrations revealed the monoester to be more active than DMSA on both parameters at each dose used, which was in good agreement with the values calculated from the excretion data. Expand
Beneficial role of monoesters of meso-2,3-dimercaptosuccinic acid in the mobilization of lead and recovery of tissue oxidative injury in rats.
TLDR
DMSA monoesters are suggested to be a better treatment option than DMSA in eliciting recovery to the altered biochemical variables and in the depletion of body lead burden. Expand
Assessment of the protective activity of monisoamyl meso-2,3-dimercaptosuccinate against methylmercury-induced maternal and embryo/fetal toxicity in mice.
TLDR
The intrinsic toxicity of Mi-ADMS would be a restrictive factor for the possible therapeutic use of this chelator in pregnant women exposed to organic mercury. Expand
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The results suggested that the Cd-binding ligands present in bile after injection of BAL and propanetrithiol were different from and had a higher molecular weight than the complexes in vitro with Cd and the respective chelating agents. Expand
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TLDR
An analysis of the manner in which mobilizing efficacy changes with structure indicates that higher, purely alkyl analogs are not expected to be superior to these compounds, though other structural variations may be. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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