Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland

@article{Johnson2003CadmiumMT,
  title={Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland},
  author={Michael D. Johnson and N. Kenney and A. Stoica and L. Hilakivi-Clarke and Baljit Singh and G. Chepko and R. Clarke and P. F. Sholler and Apolonio A Lirio and C. Foss and R. Reiter and B. Trock and S. Paik and M. Martin},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={1081-1084}
}
It has been suggested that environmental contaminants that mimic the effects of estrogen contribute to disruption of the reproductive systems of animals in the wild, and to the high incidence of hormone-related cancers and diseases in Western populations. Previous studies have shown that functionally, cadmium acts like steroidal estrogens in breast cancer cells as a result of its ability to form a high-affinity complex with the hormone binding domain of the estrogen receptor. The results of the… Expand
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