Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland

  title={Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland},
  author={Michael D. Johnson and Nicholas Kenney and Adriana Stoica and Leena Hilakivi-Clarke and Baljit Singh and Gloria Chepko and Robert Clarke and Peter F Sholler and Apolonio A Lirio and Colby Foss and Ronald Reiter and Bruce P Trock and Soonmyoung Paik and Mary Beth Martin},
  journal={Nature Medicine},
It has been suggested that environmental contaminants that mimic the effects of estrogen contribute to disruption of the reproductive systems of animals in the wild, and to the high incidence of hormone-related cancers and diseases in Western populations. Previous studies have shown that functionally, cadmium acts like steroidal estrogens in breast cancer cells as a result of its ability to form a high-affinity complex with the hormone binding domain of the estrogen receptor. The results of the… CONTINUE READING
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