Cadmium induces c-myc, p53, and c-jun expression in normal human prostate epithelial cells as a prelude to apoptosis.

@article{Achanzar2000CadmiumIC,
  title={Cadmium induces c-myc, p53, and c-jun expression in normal human prostate epithelial cells as a prelude to apoptosis.},
  author={William E Achanzar and Karen Achanzar and James G. Lewis and Mukta M. Webber and Michael P. Waalkes},
  journal={Toxicology and applied pharmacology},
  year={2000},
  volume={164 3},
  pages={291-300}
}
Cadmium is a suspected human prostatic carcinogen shown to induce prostatic tumors and proliferative lesions in rats. The carcinogenic mechanism of cadmium is unknown, but its poor mutagenicity points toward an epigenetic mechanism. Here we studied the effect of cadmium on genes involved in growth regulation of prostate epithelial cell using the human prostate epithelial cell line RWPE-1, which is immortalized but not transformed and is androgen-responsive. Treatment with 10 microM cadmium… CONTINUE READING

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