Cadmium induces both pyruvate kinase and Na+/H+ exchanger activity through protein kinase C mediated signal transduction, in isolated digestive gland cells of Mytilus galloprovincialis (L.).

@article{Dailianis2004CadmiumIB,
  title={Cadmium induces both pyruvate kinase and Na+/H+ exchanger activity through protein kinase C mediated signal transduction, in isolated digestive gland cells of Mytilus galloprovincialis (L.).},
  author={Stefanos Dailianis and Martha Kaloyianni},
  journal={The Journal of experimental biology},
  year={2004},
  volume={207 Pt 10},
  pages={1665-74}
}
The present study investigates the transduction pathway mediated by cadmium in isolated digestive gland cells of mussel Mytilus galloprovincialis. The effects of cadmium treatment on a key glycolytic enzyme, pyruvate kinase (PK), and on Na(+)/H(+) exchanger activity were examined. Cadmium (50 micro mol l(-1)) caused a significant elevation of intracellular pH (pHi) and a rise (176%) of Na influx relative to control values. The amiloride analogue, EIPA (20 nmol l(-1)), a Na(+)/H(+) exchanger… CONTINUE READING