Cadmium-induced synthesis of metallothioneins in human lymphocytes and monocytes.

  title={Cadmium-induced synthesis of metallothioneins in human lymphocytes and monocytes.},
  author={Tomofumi Sone and Shinji Koizumi and Masayasu Kimura},
  journal={Chemico-biological interactions},
  volume={66 1-2},
Cd2+-binding proteins of peripheral blood lymphocytes and monocytes have not well been characterized so far, although they are expected to be a clue for understanding Cd2+ toxicity in those immune competent cells. We separated a family of Cd2+-binding proteins from Cd2+-exposed human peripheral blood lymphocytes by gel filtration chromatography, and characterized them by SDS-gel electrophoresis. The proteins showed electrophoretic behaviours closely similar to metallothioneins (MTs) of HeLa… CONTINUE READING
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