Cadmium-induced osteomalacic and osteopetrotic lesions in ovariectomized rats.

  title={Cadmium-induced osteomalacic and osteopetrotic lesions in ovariectomized rats.},
  author={Osamu Katsuta and Hideaki Hiratsuka and Jiro Matsumoto and Hiroshi Matsuo Akira Iwata and Naoto Toyota and Minoru Tsuchitani and Takashi Umemura and Fumiaki Marumo},
  journal={Toxicology and applied pharmacology},
  volume={126 1},
The effects of long-term administration of cadmium (Cd) chloride on the bone were studied using ovariectomized rats. The rats were injected iv with the compound at doses of 1.0 and 2.0 mg/kg, 5 days a week, for 13 weeks. The serum concentrations of calcium and inorganic phosphorus were significantly increased from 8 weeks in the 2.0 mg/kg group. The bone Cd content was gradually increased for 13 weeks in a dose-dependent manner. Calcium and phosphorus contents in the bone, and serum levels of… CONTINUE READING
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