Cadmium-induced malignant transformation of human prostate epithelial cells.

  title={Cadmium-induced malignant transformation of human prostate epithelial cells.},
  author={William E Achanzar and Bhalchandra A. Diwan and Jinsong Liu and Salmaan T A Quader and Mukta M. Webber and Michael P. Waalkes},
  journal={Cancer research},
  volume={61 2},
Prostate cancer has become epidemic, and environmental factors such as cadmium may be partly responsible. This study reports malignant transformation of the nontumorigenic human prostatic epithelial cell line RWPE-1 by in vitro cadmium exposure. The cadmium-transformed cells exhibited a loss of contact inhibition in vitro and rapidly formed highly invasive and occasionally metastatic adenocarcinomas upon inoculation into mice. The transformed cells also showed increased secretion of MMP-2 and… CONTINUE READING

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Role of cadmium in the etiology of cancer of the prostate

  • M. P. Waalkes, S. Rehm, T. P. Coogan, J. M. Ward
  • Endocrine Toxicology, Ed
  • 1997
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