Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes.

@article{Zou2019CadmiuminducedCI,
  title={Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes.},
  author={Hui Zou and Tao Wang and Junzhao Yuan and Jian Sun and Yan Yuan and Jianhong Gu and Xuezhong Liu and Jianchun Bian and Zongping Liu},
  journal={Toxicology letters},
  year={2019}
}

Puerarin Restores Autophagosome-Lysosome Fusion to Alleviate Cadmium-Induced Autophagy Blockade via Restoring the Expression of Rab7 in Hepatocytes

TLDR
Pue-mediated alleviation of Cd-induced hepatocyte injury was related to the activation of autophagy and the alleviation in hepatocytes ofAutophagic dysfunction, and Pue restored the fusion of Autophagosomes and lysosomes by restoring the protein expression of Rab7, thereby alleviating Cd's autophagic blockade in hepatocyte cells.

Cadmium affects autophagy in the human intestinal cells Caco-2 through ROS-mediated ERK activation.

TLDR
The results prompt further studies investigating the consequences that Cd-induced ERK1/2 activation and the related effect on autophagy may have on the intestinal cells, which may accumulate and trap high levels of Cd under some nutritional conditions.

Gap Junction Intercellular Communication Negatively Regulates Cadmium-Induced Autophagy and Inhibition of Autophagic Flux in Buffalo Rat Liver 3A Cells

TLDR
During this process, inhibiting of GJIC could exacerbate the cytotoxic damage of cadmium and induce autophagy, but further blocked autophagic flux, promoting GJ IC in order to obtain the opposite results.

Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases

TLDR
Recent developments and findings regarding the role of Cd in the modulation of hepatotoxicity, autophagic function, and liver diseases at the molecular level are reviewed.

Cadmium cytotoxicity and possible mechanisms in human trophoblast HTR‐8/SVneo cells

TLDR
In this study, Cd cytotoxicity and its mechanisms in HTR‐8/SVneo cells were investigated and Cd disrupted the cellular submicrostructure and inhibited the cell viability in a time‐ and dose‐dependent manner.

Chronic Oral Exposure to Cadmium Causes Liver Inflammation by NLRP3 Inflammasome Activation in Pubertal Mice.

  • Xusheng LiHaiwei Li Weibin Bai
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2020

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