Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes.

@article{Zou2019CadmiuminducedCI,
  title={Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes.},
  author={Hui Zou and Tao Wang and Junzhao Yuan and Jian Sun and Yan Yuan and Jianhong Gu and Xuezhong Liu and Jianchun Bian and Zongping Liu},
  journal={Toxicology letters},
  year={2019}
}
Cadmium (Cd) is an important environmental pollutant. Previous studies have shown that Cd can induce liver cell injury; however, the toxicity mechanisms of Cd have not been fully elucidated. This study aimed to further confirm the hepatotoxic effects of Cd in mouse liver cells by various methods both in vivo and in vitro. In addition, it found that Cd induced autophagy but also caused autophagy blockade, and autophagy blockade intensified Cd-induced injury in liver cells. Subsequently, the… Expand
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