Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes.

  title={Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes.},
  author={Hui Zou and Tao Wang and Junzhao Yuan and Jian Sun and Yan Yuan and Jianhong Gu and Xuezhong Liu and Jianchun Bian and Zongping Liu},
  journal={Toxicology letters},

Puerarin Restores Autophagosome-Lysosome Fusion to Alleviate Cadmium-Induced Autophagy Blockade via Restoring the Expression of Rab7 in Hepatocytes

Pue-mediated alleviation of Cd-induced hepatocyte injury was related to the activation of autophagy and the alleviation in hepatocytes ofAutophagic dysfunction, and Pue restored the fusion of Autophagosomes and lysosomes by restoring the protein expression of Rab7, thereby alleviating Cd's autophagic blockade in hepatocyte cells.

Cadmium affects autophagy in the human intestinal cells Caco-2 through ROS-mediated ERK activation.

The results prompt further studies investigating the consequences that Cd-induced ERK1/2 activation and the related effect on autophagy may have on the intestinal cells, which may accumulate and trap high levels of Cd under some nutritional conditions.

Gap Junction Intercellular Communication Negatively Regulates Cadmium-Induced Autophagy and Inhibition of Autophagic Flux in Buffalo Rat Liver 3A Cells

During this process, inhibiting of GJIC could exacerbate the cytotoxic damage of cadmium and induce autophagy, but further blocked autophagic flux, promoting GJ IC in order to obtain the opposite results.

Role of Autophagy in Cadmium-Induced Hepatotoxicity and Liver Diseases

Recent developments and findings regarding the role of Cd in the modulation of hepatotoxicity, autophagic function, and liver diseases at the molecular level are reviewed.

Cadmium cytotoxicity and possible mechanisms in human trophoblast HTR‐8/SVneo cells

In this study, Cd cytotoxicity and its mechanisms in HTR‐8/SVneo cells were investigated and Cd disrupted the cellular submicrostructure and inhibited the cell viability in a time‐ and dose‐dependent manner.

Chronic Oral Exposure to Cadmium Causes Liver Inflammation by NLRP3 Inflammasome Activation in Pubertal Mice.

  • Xusheng LiHaiwei Li Weibin Bai
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2020



Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells

Pb-mediated autophagy blockade in rPT cells is attributed to the impairment of lysosomal function, and both inhibition of autophagic flux and LMP-mediated apoptosis contribute to Pb-induced nephrotoxicity in r PT cells.

Induction of cytoprotective autophagy in PC-12 cells by cadmium.

ERK1/2 MAPK promotes autophagy to suppress ER stress-mediated apoptosis induced by cadmium in rat proximal tubular cells.

The relationship between Cd‐induced autophagy and lysosomal activation in WRL‐68 cells

It is found that Cd induces autophagy in the human's embryonic normal liver cell line (WRL‐68) and the relationship between autophagosome–lysosome fusion and pH in acidic compartments by visualizing fusion process in WRL‐ 68 cells, and the activation of lysosomal function was associated with Ca2- stores and intracellular Ca2+ channels or pumps were possibly pH‐dependent.

Autophagy in exposure to environmental chemicals.

Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A

It is found that vacuolin-1 potently and reversibly inhibited the fusion between autophagosomes and lysosomes in mammalian cells, thereby inducing the accumulation of autophagy.

Mechanisms of cadmium‐mediated acute hepatotoxicity

It is clear that Kupffer cell activation and neutrophil infiltration are important events in the toxic process, and the involvement of proinflammatory cytokines and chemokines has also been implicated; the precise roles of the soluble mediators of inflammation warrant further investigation.

Autophagy in the liver: functions in health and disease

A growing body of evidence has shown that liver autophagy contributes to basic hepatic functions, including glycogenolysis, gluconeogenesis and β-oxidation, through selective turnover of specific cargos controlled by a series of transcription factors.