Cadmium-induced changes in Per 1 and Per 2 gene expression in rat hypothalamus and anterior pituitary: effect of melatonin.

@article{Cano2007CadmiuminducedCI,
  title={Cadmium-induced changes in Per 1 and Per 2 gene expression in rat hypothalamus and anterior pituitary: effect of melatonin.},
  author={Pilar Cano and Ariel Hern{\'a}n Poliandri and Vanessa Jim{\'e}nez and Daniel P. Cardinali and Ana Isabel Esquifino},
  journal={Toxicology letters},
  year={2007},
  volume={172 3},
  pages={131-6}
}
Chronic cadmium (Cd) administration affects the circadian release of pituitary hormones in rats. To assess whether Cd modifies expression of two major clock genes, period (Per) 1 and Per 2, in the hypothalamic-pituitary unit and to what extent the changes could be prevented by melatonin, rats were exposed to CdCl(2) (5ppm in drinking water) with or without melatonin (3 microg/mL drinking water) for 1 month and were killed at two time intervals, i.e. a the beginning of the rest span (09:00h) and… CONTINUE READING

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