Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway

@article{Wang2008CadmiuminducedAA,
  title={Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway},
  author={Su Hua Wang and Ya Lan Shih and Wen Ching Ko and Yau Huei Wei and Chwen Ming Shih},
  journal={Cellular and Molecular Life Sciences},
  year={2008},
  volume={65},
  pages={3640-3652}
}
The cytotoxicity of cadmium (Cd) induced autophagy and apoptosis in MES-13 cells was determined by flow cytometry. Autophagy was also assessed by formation of autophagosomes and processing of LC3. Pharmacological inhibition of autophagy resulted in increased of cell viability, suggesting autophagy plays a role in cell death in Cd-treated mesangial cells. Cd also induced a rapid elevation in cytosolic calcium ([Ca2+]i ), and modulation of [Ca2+]i via treatment with IP 3R inhibitor or knockdown… CONTINUE READING
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