Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis.

@article{Li2003CadmiumDI,
  title={Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis.},
  author={Min Li and Tian Xia and Chun-sun Jiang and Lin-Jiang Li and Juan-Ling Fu and Zong-can Zhou},
  journal={Toxicology},
  year={2003},
  volume={194 1-2},
  pages={19-33}
}
The mitochondrial damage induced by cadmium has been well established, but its mechanism and its relationship with cadmium-induced apoptosis are elusive until now. Our research showed that cadmium could directly lead to the dysfunction of isolated mitochondria from mouse liver, including the inhibition of respiration, the opening of permeability transition pore (PTP), the loss of transmembrane potential, and the release of cytochrome c. These mitochondrial changes were completely suppressed by… CONTINUE READING

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