Cadmium coordination to the zinc binding domains of the non-classical zinc finger protein Tristetraprolin affects RNA binding selectivity.


Tristetraprolin [(TTP), also known as NUP475 and TIS11] is a non-classical zinc finger protein that regulates inflammatory response via a protein-RNA interaction. Specifically, TTP recognizes AU-rich RNA sequences located on the 3' untranslated region of messenger RNA associated with cytokines. Recently, TTP was shown to be upregulated when cells were… (More)
DOI: 10.1016/j.jinorgbio.2012.02.023


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