Cadmium-chloride-induced air-space enlargement with interstitial pulmonary fibrosis is not associated with destruction of lung elastin. Implications for the pathogenesis of human emphysema.

@article{Snider1988CadmiumchlorideinducedAE,
  title={Cadmium-chloride-induced air-space enlargement with interstitial pulmonary fibrosis is not associated with destruction of lung elastin. Implications for the pathogenesis of human emphysema.},
  author={Gordon L. Snider and Edgar C. Lucey and Barbara Faris and Y J Jung-Legg and Phillip J. Stone and Carl Franzblau},
  journal={The American review of respiratory disease},
  year={1988},
  volume={137 4},
  pages={918-23}
}
To determine whether lung elastin is lost during the evolution of cadmium-induced air-space enlargement with pulmonary fibrosis, the lung elastin of 5- to 7-day-old golden Syrian hamster pups was radiolabeled by giving [3H]valine. At maturity, a single intratracheal instillation of 0.5 ml of 0.025% CdCl2 solution was given. Lung mechanics, histologic examination, and biochemistry were studied 5, 10, 21, 42, 105, and 180 days after the cadmium treatment. The animals developed fibrosis and air… CONTINUE READING