Cadmium carcinogenesis in male Wistar [Crl:(WI)BR] rats: dose-response analysis of effects of zinc on tumor induction in the prostate, in the testes, and at the injection site.

@article{Waalkes1989CadmiumCI,
  title={Cadmium carcinogenesis in male Wistar [Crl:(WI)BR] rats: dose-response analysis of effects of zinc on tumor induction in the prostate, in the testes, and at the injection site.},
  author={Michael P. Waalkes and Sabine Rehm and Charles Warburton Riggs and Robert M Bare and Deborah E. Devor and Lionel A. Poirier and Martin L. Wenk and J R Henneman},
  journal={Cancer research},
  year={1989},
  volume={49 15},
  pages={
          4282-8
        }
}
The ability of zinc acetate to modify the carcinogenic effects of CdCl2 in male Wistar [Crl:(WI)BR] rats was studied over a 2-year period. Groups of rats received a single s.c. injection of Cd (30.0 mumol/kg) in the dorsal thoracic midline or i.m. in the right thigh at time 0. Zinc was given in three separate s.c. doses of 0.1, 0.3, or 1.0 mmol/kg (at -6, 0, and +18 h relative to cadmium) in the lumbosacral area or p.o. at 100 ppm in the drinking water (-2 to +100 weeks). Cadmium treatments (s… CONTINUE READING

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