Cadmium blocks receptor-mediated Jak/STAT signaling in neurons by oxidative stress.

@article{Monroe2006CadmiumBR,
  title={Cadmium blocks receptor-mediated Jak/STAT signaling in neurons by oxidative stress.},
  author={Richard K Monroe and Stanley W. Halvorsen},
  journal={Free radical biology & medicine},
  year={2006},
  volume={41 3},
  pages={493-502}
}
Cadmium is an environmental contaminant producing numerous pathological effects including neurological disorders. The mechanisms through which cadmium produces neurotoxicities are not completely known. We found that divalent cadmium (CdCl2) inhibited ciliary neurotrophic factor (CNTF)-mediated Jak1 and Jak2 tyrosine kinase signaling in human BE(2)-C neuroblastoma cells. CdCl2 concentrations as low as 0.1 microM and for times as brief as 2 h significantly reduced CNTF-induced tyrosine… CONTINUE READING

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