Cadmium block of calcium current in frog sympathetic neurons.

@article{Thvenod1992CadmiumBO,
  title={Cadmium block of calcium current in frog sympathetic neurons.},
  author={Frank Th{\'e}venod and S. W. Maslen Jones},
  journal={Biophysical journal},
  year={1992},
  volume={63 1},
  pages={
          162-8
        }
}
Cd2+ blocks whole-cell calcium currents in frog sympathetic neurons by 50% at approximately 300 nM. Strong depolarizations rapidly reverse that blockade (tau = 1.3 ms at +120 mV). Reblocking follows bimolecular kinetics (rate = 1.2 x 10(8) M-1 s-1) at voltages where channels are mostly open (0 to +30 mV). The unblocking rate is approximately 50 s-1, so the dissociation constant calculated from the rate constants is approximately 400 nM. Steady-state block is strong at -80 mV, so closed channels… CONTINUE READING
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