Cadmium and cellular signaling cascades: interactions between cell death and survival pathways

@article{Thvenod2013CadmiumAC,
  title={Cadmium and cellular signaling cascades: interactions between cell death and survival pathways},
  author={Frank Th{\'e}venod and Wing-kee Lee},
  journal={Archives of Toxicology},
  year={2013},
  volume={87},
  pages={1743-1786}
}
Cellular stress elicited by the toxic metal Cd2+ does not coerce the cell into committing to die from the onset. Rather, detoxification and adaptive processes are triggered concurrently, allowing survival until normal function is restored. With high Cd2+, death pathways predominate. However, if sublethal stress levels affect cells for prolonged periods, as in chronic low Cd2+ exposure, adaptive and survival mechanisms may deregulate, such that tumorigenesis ensues. Hence, death and malignancy… CONTINUE READING
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