Cadmium alters the localization of N-cadherin, E-cadherin, and beta-catenin in the proximal tubule epithelium.

@article{Prozialeck2003CadmiumAT,
  title={Cadmium alters the localization of N-cadherin, E-cadherin, and beta-catenin in the proximal tubule epithelium.},
  author={Walter C. Prozialeck and Peter C. Lamar and Sean M Lynch},
  journal={Toxicology and applied pharmacology},
  year={2003},
  volume={189 3},
  pages={180-95}
}
Recent studies on proximal tubule-derived cells in culture have shown that Cd has relatively specific damaging effects on the cadherin-dependent junctions between the cells. The objective of the present study was to determine whether Cd can affect cadherin-dependent junctions in the proximal tubule epithelium in vivo. Male Sprague-Dawley rats received subcutaneous injections of Cd (0.6 mg/kg in isotonic saline, 5 days per week for up to 6 weeks). One day each week, 24-h urine samples were… CONTINUE READING