Cadmium Impairs Albumin Reabsorption by Down-regulating Megalin and ClC5 Channels in Renal Proximal Tubule Cells

@inproceedings{Gena2010CadmiumIA,
  title={Cadmium Impairs Albumin Reabsorption by Down-regulating Megalin and ClC5 Channels in Renal Proximal Tubule Cells},
  author={Patrizia Gena and Giuseppe Calamita and William B Guggino},
  booktitle={Environmental health perspectives},
  year={2010}
}
BACKGROUND Cadmium (Cd) is a potent nephrotoxicant that impairs the reabsorptive and secretory functions of the renal proximal tubule, leading to albuminuria. OBJECTIVES To gain insights into the mechanisms of Cd-induced albuminuria, we investigated effects of Cd on the expression of megalin and chloride channel 5 (ClC5), two key players in albumin-receptor-mediated endocytosis. METHODS We used quantitative polymerase chain reaction, Western blotting, the albumin endocytosis assay, and… CONTINUE READING
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