Cadmium (Cd2+) disrupts intercellular junctions and actin filaments in LLC-PK1 cells.

@article{Prozialeck1991CadmiumD,
  title={Cadmium (Cd2+) disrupts intercellular junctions and actin filaments in LLC-PK1 cells.},
  author={Walter C. Prozialeck and Robert Niewenhuis},
  journal={Toxicology and applied pharmacology},
  year={1991},
  volume={107 1},
  pages={81-97}
}
Studies reported in the literature suggest that cadmium (Cd2+) may disrupt the junctions between cells in some tissues and cell culture systems. In order to examine this possibility in more detail, we have studied the effects of Cd2+ on the integrity of intercellular junctions in the established porcine renal epithelial cell line, LLC-PK1. Junctional integrity was assessed by monitoring the collapse of domes and by measuring changes in the transepithelial electrical resistance in confluent cell… CONTINUE READING

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