Cadherins in Wilms' tumor: E-cadherin expression despite absence of WT1.

@article{Baudry2003CadherinsIW,
  title={Cadherins in Wilms' tumor: E-cadherin expression despite absence of WT1.},
  author={Dominique Baudry and M O Cabanis and Catherine Patte and J. -M. Zucker and François Pein and Jean-Christophe Fournet and S. Sarnacki and Claudine Junien and C{\'e}cile Jeanpierre},
  journal={Anticancer research},
  year={2003},
  volume={23 1A},
  pages={475-8}
}
Loss of heterozygosity of chromosome 16q occurs in 17-25% of Wilms' tumors. Two cadherin genes mapping to 16q22 were chosen as candidate gens: E-CAD, encoding epithelial cadherin, because it is involved in kidney development and it was recently reported to be a WT1 target; and KSP-CAD because it encodes a kidney-specific cadherin. By RT-PCR analysis in a series of 39 Wilms' tumors, we identified a very low expression of E-CAD and KSP-CAD in 72% and 95% of the tumors, respectively. To ascertain… CONTINUE READING

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