Cadherins and tissue formation: integrating adhesion and signaling.

  title={Cadherins and tissue formation: integrating adhesion and signaling.},
  author={Kris Vleminckx and Rolf Kemler},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={21 3},
Cadherins and other cell-substrate and cell-cell adhesion molecules play an essential role during development. Through their cytoplasmic interaction with the cytoskeleton, cell adhesion molecules physically link cells with the extracellular matrix and/or with each other. These interactions create architectural and structural entities that enable the tissues in the embryo to restrain the physical forces encountered during development. Regulated cell adhesion is also often the driving force of… CONTINUE READING