Cadherins and the tumour progression: is it all in a switch?

  title={Cadherins and the tumour progression: is it all in a switch?},
  author={Ugo Cavallaro and Birgit Schaffhauser and Gerhard Christofori},
  journal={Cancer letters},
  volume={176 2},
Progression to tumour malignancy involves changes in a tumour cell's capabilities to adhere and communicate with neighboring cells and with its extracellular environment. Correlation studies in human cancer specimen and functional experiments with cultured tumour cells and transgenic mouse models have indicated that the loss of the cell adhesion molecule E-cadherin is causally involved in the formation of epithelial cancers (carcinomas). More recently, it has been observed that the function of… CONTINUE READING

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