Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

@article{Jeanes2008CadherinsAC,
  title={Cadherins and cancer: how does cadherin dysfunction promote tumor progression?},
  author={Angela Jeanes and Cara J Gottardi and Alpha S. Yap},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={6920-6929}
}
It has long been recognized that the cell–cell adhesion receptor, E-cadherin, is an important determinant of tumor progression, serving as a suppressor of invasion and metastasis in many contexts. Yet how the loss of E-cadherin function promotes tumor progression is poorly understood. In this review, we focus on three potential underlying mechanisms: the capacity of E-cadherin to regulate β-catenin signaling in the canonical Wnt pathway; its potential to inhibit mitogenic signaling through… CONTINUE READING
Blog posts, news articles and tweet counts and IDs sourced by
Altmetric.com