Cadherins, catenins and APC in pleural malignant mesothelioma

@article{Abutaily2003CadherinsCA,
  title={Cadherins, catenins and APC in pleural malignant mesothelioma},
  author={A. S. Abutaily and J. Collins and W. Roche},
  journal={The Journal of Pathology},
  year={2003},
  volume={201}
}
Malignant mesothelioma is an aggressive disease of the pleura, and less commonly the peritoneum, with a very poor prognosis. The present study has examined the expression of cell adhesion molecules including cadherins, catenins, and APC in order to determine whether abnormal expression of components of the Wnt signalling pathway contribute to the variable phenotype of malignant mesothelioma. Sixty‐three malignant mesotheliomas and nine cases of reactive mesothelial hyperplasia were analysed by… Expand
β-catenin expression in benign and malignant pleural disorders.
TLDR
IHC for β-catenin does not appear to be conclusive for separating benign from malignant mesothelial proliferations, but may be valuable for assisting in the differential diagnosis of mesothelioma and spindle cell proliferations in the pleura. Expand
Expression of E-Cadherin, β-Catenin and APC protein in Canine Colorectal Tumours
TLDR
The changes in adhesion molecules can play a very important role both in colorectal carcinogenesis and in malignant progression; moreover, these proteins can also be considered powerful prognostic tools in veterinary oncology. Expand
TLE1 expression in malignant mesothelioma
TLDR
This study showed no or limited value of the immunohistochemical TLE1 expression in distinguishing malignant mesothelioma and synovial sarcoma. Expand
CK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells
TLDR
It is reported for the first time that over-expressed CK2α positively regulate Hh/Gli1 signaling in human mesothelioma. Expand
Expression of β-Catenin, E-cadherin and APC in Canine Mammary Tumors
TLDR
The results may indicate the multifunctional role played by ‚-catenin in canine mammary oncogenesis, which could be linked to mutations in ‘- catenin gene coding for a truncated and lighter protein. Expand
Expression of snail, twist, and Zeb1 in malignant mesothelioma
TLDR
Snail expression is associated with poor prognosis in lung adenocarcinomas, but an opposite effect was seen in mesothelioma, a fact which may be related to the different cellular origin of epithelial and mesothelial cells. Expand
Expression of Cancer-Associated Molecules in Malignant Mesothelioma
TLDR
Current knowledge regarding the biological characteristics of this disease that are linked to the so-called hallmarks of cancer are presented and data suggesting that the anatomic site (solid tumor vs. effusion) affects the expression of metastasis-associated and regulatory molecules in MM are presented. Expand
Wnt2 as a new therapeutic target in malignant pleural mesothelioma
TLDR
It is proposed that inhibition of Wnt2 is of therapeutic interest in the development of more effective treatments for MPM and the effects of the anti‐Wnt2 antibody and of Alimta on MPM cell proliferation. Expand
Expression profile and function of Wnt signaling mechanisms in malignant mesothelioma cells.
TLDR
Evidence is provided for altered expression of a number of Wnt/Fzd signaling molecules in MM that may prove a means of targeting proliferation and drug resistance in this cancer. Expand
Molecular Pathways: Targeting Mechanisms of Asbestos and Erionite Carcinogenesis in Mesothelioma
TLDR
Novel strategies that interfere with asbestos- and erionite-mediated inflammation might prevent or delay the onset of mesothelioma in high-risk cohorts, including genetically predisposed individuals, and/or inhibit tumor growth. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 59 REFERENCES
Immunohistochemistry in the distinction between malignant mesothelioma and pulmonary adenocarcinoma: a critical evaluation of new antibodies
Aim: The value of immunohistochemical staining in differentiating between malignant mesothelioma and pulmonary adenocarcinoma was re-examined using newly available commercial antibodies, with the aimExpand
Mutations in the β-Catenin Gene (CTNNB1) in Endometrioid Ovarian Carcinomas
TLDR
The results implicate beta-catenin gene mutations in ovarian malignant transformation with a characteristic phenotype: endometrioid ovarian carcinoma. Expand
Frequent β‐Catenin Abnormalities in Bone and Soft‐tissue Tumors
TLDR
The results suggested the possible involvement of β‐Catenin activation, by β‐catenin gene mutation or alteration of other factor(s), in the formation and/or progression of various types of bone and soft‐tissue tumors. Expand
Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas.
TLDR
The results implicate beta-catenin gene mutations in ovarian malignant transformation with a characteristic phenotype: endometrioid ovarian carcinoma. Expand
Abnormal alpha-catenin expression in invasive breast cancer correlates with poor patient survival.
AIMS alpha-Catenin is a member of the E-cadherin-catenin family of adhesion molecules whose role is essential for the function of the E-cadherin complex. In this study, we have evaluated theExpand
Alteration of β‐catenin expression in esophageal squamous‐cell carcinoma
TLDR
Results indicate that alterations of the cadherin‐catenin complex may play an important role in a sub‐set of esophageal carcinogenesis and it is suggested that β‐Catenin over‐expression is not caused by genetic alteration of either the β‐ catenin or the APC gene. Expand
Beta-catenin mutation in carcinoma of the uterine endometrium.
TLDR
Investigation of mutations in exon 3 of the beta-catenin gene in endometrial carcinoma cases in which loss of heterozygosity at the adenomatous polyposis coli tumor suppressor gene locus has been rarely reported indicates that stabilization of beta-Catenin due to mutations inExon 3of the beta/threonine residues and other mechanisms may have an important role in development of endometrian carcinomas. Expand
Reduced expression of α-catenin, β-catenin, and γ-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer
TLDR
The expression of α, β, and γ-catenin is related to histological type and differentiation in NSCLC, although catenins have no independent prognostic value, however, this study supports the important role of the nuclear accumulation of β- catenin and ε-catanin in highly proliferative cells. Expand
Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.
TLDR
The high frequency of activating mutations in the beta-catenin gene indicates an important role in the pathogenesis of HB. Expand
Sporadic Medulloblastomas Contain Oncogenic β-Catenin Mutations
TLDR
Data suggest that activating mutations in the β- catenin gene may be involved in the development of a subset of medulloblastomas, and that the GSK-3 β gene does not appear to be a target for inactivation in this tumor. Expand
...
1
2
3
4
5
...