Cadherin transfection of Xenopus XTC cells downregulates expression of substrate adhesion molecules.

@article{Finnemann1995CadherinTO,
  title={Cadherin transfection of Xenopus XTC cells downregulates expression of substrate adhesion molecules.},
  author={Silvia C. Finnemann and Michael K{\"u}hl and G. F. Otto and Doris Wedlich},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 9},
  pages={5082-91}
}
Cadherins are discussed not in terms of their adhesive function but rather as morphoregulatory proteins. Changes in gene expression following cadherin transfection of cells in culture or by overexpression in embryos have, until now, not been reported. We established a protocol for stable transfection of Xenopus XTC cells and generated cells bearing high levels of membrane-integrated mouse uvomorulin (E-cadherin) or Xenopus XB-cadherin. These cell lines showed drastically impaired substrate… CONTINUE READING