Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication.

@article{Bochkov2015CadherinrelatedFM,
  title={Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication.},
  author={Yury Alexandrovich Bochkov and Kelly E. Watters and Shamaila Ashraf and Theodor F. Griggs and Mark K. Devries and Daniel John Jackson and Ann C. Palmenberg and James E Gern},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 17},
  pages={5485-90}
}
Members of rhinovirus C (RV-C) species are more likely to cause wheezing illnesses and asthma exacerbations compared with other rhinoviruses. The cellular receptor for these viruses was heretofore unknown. We report here that expression of human cadherin-related family member 3 (CDHR3) enables the cells normally unsusceptible to RV-C infection to support both virus binding and replication. A coding single nucleotide polymorphism (rs6967330, C529Y) was previously linked to greater cell-surface… CONTINUE READING
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References

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A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

  • K Bønnelykke
  • Nat Genet
  • 2014

Rhinovirus chemotherapy

  • R Privolizzi, R Solari, SL Johnston, GR McLean
  • Antiviral Res
  • 2014

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