Cadherin-11, a marker of the mesenchymal phenotype, regulates glioblastoma cell migration and survival in vivo.

@article{Kaur2012Cadherin11AM,
  title={Cadherin-11, a marker of the mesenchymal phenotype, regulates glioblastoma cell migration and survival in vivo.},
  author={Harpreet Kaur and Polly J Phillips-Mason and Susan M. Burden-Gulley and Amber E Kerstetter-Fogle and James P. Basilion and Andrew E. Sloan and Susann M Brady-Kalnay},
  journal={Molecular cancer research : MCR},
  year={2012},
  volume={10 3},
  pages={293-304}
}
Glioblastoma multiforme (GBM) is the most malignant and lethal form of astrocytoma. The GBM patient survival time of approximately 1 year necessitates the identification of novel molecular targets and more effective therapeutics. Cadherin-11, a calcium-dependent cell-cell adhesion molecule and mesenchymal marker, plays a role in both normal tissue development and in cancer cell migration. The functional significance of cadherin-11 in GBM has not been investigated. Here, we show that cadherin-11… CONTINUE READING

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