Cadherin, alkaline phosphatase, and aminopeptidase N as receptors of Cry11Ba toxin from Bacillus thuringiensis subsp. jegathesan in Aedes aegypti.

@article{Likitvivatanavong2011CadherinAP,
  title={Cadherin, alkaline phosphatase, and aminopeptidase N as receptors of Cry11Ba toxin from Bacillus thuringiensis subsp. jegathesan in Aedes aegypti.},
  author={Supaporn Likitvivatanavong and Jianwu Chen and Alejandra Bravo and Mario Sober{\'o}n and Sarjeet S. Gill},
  journal={Applied and environmental microbiology},
  year={2011},
  volume={77 1},
  pages={24-31}
}
Cry11Ba is one of the most toxic proteins to mosquito larvae produced by Bacillus thuringiensis. It binds Aedes aegypti brush border membrane vesicles (BBMV) with high affinity, showing an apparent dissociation constant (K(d)) of 8.2 nM. We previously reported that an anticadherin antibody competes with Cry11Ba binding to BBMV, suggesting a possible role of cadherin as a toxin receptor. Here we provide evidence of specific cadherin repeat regions involved in this interaction. Using cadherin… CONTINUE READING

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