CadC is the preferential target of a convergent evolution driving enteroinvasive Escherichia coli toward a lysine decarboxylase-defective phenotype.

@article{Casalino2003CadCIT,
  title={CadC is the preferential target of a convergent evolution driving enteroinvasive Escherichia coli toward a lysine decarboxylase-defective phenotype.},
  author={Mariassunta Casalino and Maria Carmela Latella and Gianni Prosseda and Bianca Colonna},
  journal={Infection and immunity},
  year={2003},
  volume={71 10},
  pages={5472-9}
}
Enteroinvasive E. coli (EIEC), like Shigella, is the etiological agent of bacillary dysentery, a particularly severe syndrome in children in developing countries. All EIEC strains share with Shigella the inability to synthesize lysine decarboxylase (the LDC phenotype). The lack of this function is considered a pathoadaptive mutation whose emergence was necessary to obtain the full expression of invasiveness. Cadaverine, the product of lysine decarboxylation, is a small polyamine which… CONTINUE READING
14 Citations
46 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Molecular cloning: a laboratory manual, 3rd ed

  • J. Sambrook, D. Russell
  • Cold Spring Harbor Laboratory,
  • 2001
Highly Influential
4 Excerpts

A short course in bacterial genetics

  • J. H. Miller
  • 1992
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…