Caco-2 adenocarcinoma on chicken embryos chorioallantoic membrane (CAM) as an alternative to mammalian models for preclinical tests of new cytostatic drug formulations


In the development of new cytostatic drug formulations targeting plays a prominent role. To test the efficacy of targeting strategies a frequent approach is to use immune-deficient nude mice grafted with tumors. The chicken embryo’s chorioallantoic membrane (CAM) is a known alternative to mammalian in vivo models (Armstrong et al., 1982; Kunzi-Rapp et al… (More)


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