Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa

@article{Hilgers1990Caco2CM,
  title={Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa},
  author={Allen R. Hilgers and Robert A. Conradi and Philip S. Burton},
  journal={Pharmaceutical Research},
  year={1990},
  volume={7},
  pages={902-910}
}
Human colon adenocarcinoma (Caco-2) cells, when grown on semipermeable filters, spontaneously differentiate in culture to form confluent monolayers which both structurally and functionally resemble the small intestinal epithelium. Because of this property they show promise as a simple, in vitro model for the study of drug absorption and metabolism during absorption in the intestinal mucosa. In the present study, the transport of several model solutes across Caco-2 cell monolayers grown in the… CONTINUE READING
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