Cachexia: pathophysiology and clinical relevance.

@article{Morley2006CachexiaPA,
  title={Cachexia: pathophysiology and clinical relevance.},
  author={J Eileen Morley and David R Thomas and M M G Wilson},
  journal={The American journal of clinical nutrition},
  year={2006},
  volume={83 4},
  pages={735-43}
}
Cachexia causes weight loss and increased mortality. It affects more than 5 million persons in the United States. Other causes of weight loss include anorexia, sarcopenia, and dehydration. The pathophysiology of cachexia is reviewed in this article. The major cause appears to be cytokine excess. Other potential mediators include testosterone and insulin-like growth factor I deficiency, excess myostatin, and excess glucocorticoids. Numerous diseases can result in cachexia, each by a slightly… CONTINUE READING
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