Cachexia, survival and the acute phase response.

  title={Cachexia, survival and the acute phase response.},
  author={Nathan A. Stephens and Richard J E Skipworth and Kenneth C H Fearon},
  journal={Current opinion in supportive and palliative care},
  volume={2 4},
PURPOSE OF REVIEW To review current knowledge of the relationship between cytokines, the acute phase response (APR) and the development of cachexia. RECENT FINDINGS Cytokines important in the initiation of the APR are also important in the genesis of cachexia. The presence of an APR or high circulating levels of pro-inflammatory cytokines are known to be related to adverse outcome in cancer patients. Studies of host cytokine genotype have demonstrated that specific host cytokine polymorphisms… CONTINUE READING

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