Cachectin and tumour necrosis factor as two sides of the same biological coin

@article{Beutler1986CachectinAT,
  title={Cachectin and tumour necrosis factor as two sides of the same biological coin},
  author={Bruce Beutler and Anthony Cerami},
  journal={Nature},
  year={1986},
  volume={320},
  pages={584-588}
}
In response to invasive stimuli, macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential. 
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