Cachectin/tumor necrosis factor: a possible mediator of cancer anorexia in the rat.

@article{Stovroff1988CachectintumorNF,
  title={Cachectin/tumor necrosis factor: a possible mediator of cancer anorexia in the rat.},
  author={Mark C. Stovroff and Douglas L. Fraker and J A Swedenborg and Jeffrey A Norton},
  journal={Cancer research},
  year={1988},
  volume={48 16},
  pages={
          4567-72
        }
}
Cachectin/tumor necrosis factor (TNF) is a macrophage product which may have a role in cancer cachexia. Recombinant human cachectin/TNF (Cetus Corporation) was administered i.p. twice daily to male F344 rats at varying, nonlethal dosages for either 5 or 10 days, and daily rat food intake and body weight were measured. There was a dose-dependent cachectin/TNF-induced decline in food intake and body weight gain over the treatment period. However, after 1 day rats became tolerant to these effects… CONTINUE READING

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