Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.

@article{Wu2001CablesEC,
  title={Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.},
  author={Chin-lee Wu and Sandra D. Kirley and Hua Xiao and Yung-Jen Chuang and Daniel C. Chung and Lawrence R. Zukerberg},
  journal={Cancer research},
  year={2001},
  volume={61 19},
  pages={7325-32}
}
Cyclin-dependent kinase 2 (cdk2) is a small serine/threonine kinase that regulates cell cycle progression. Cdk2 activity is tightly controlled by several mechanisms, including phosphorylation and dephosphorylation events. Cables is a recently described novel cdk-interacting protein. In proliferating cells, Cables was predominantly localized in the nucleus by cell fractionation and immunostaining. Expression of Cables in HeLa cells inhibited cell growth and colony formation. Cables enhanced cdk2… CONTINUE READING

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