Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth

@article{Zukerberg2000CablesLC,
  title={Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth},
  author={Lawrence R. Zukerberg and Gentry N Patrick and Margareta Nikoli{\'c} and Sandrine Humbert and Chin-Lee Wu and Lorene M. Lanier and Frank B. Gertler and Marc Vidal and Richard A. Van Etten and Li-Huei Tsai},
  journal={Neuron},
  year={2000},
  volume={26},
  pages={633-646}
}
Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.
TLDR
Evidence is provided for a Cables-mediated interplay between cdk2 and Wee1 that leads to inhibition of cell growth, and loss of Cables may cause uncontrolled cell growth and enhance tumor formation.
The acetylation of cyclin-dependent kinase 5 at lysine 33 regulates kinase activity and neurite length in hippocampal neurons
TLDR
A novel mechanism by which acetylation-mediated regulation of nuclear CDK5 activity plays a critical role in determining neurite length in embryonic neurons is identified.
The Kinase Activity of Cdk5 and Its Regulation
TLDR
The enzymatic properties and the regulation mechanisms of Cdk5 activity in post-mitotic neurons in comparison to cell cycle Cdks are described and deregulation of the activity is induced by the cleavage of p35 to p25 by calpain, leading to hyperactivation and eventually neuronal cell death.
Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5*
TLDR
The results indicate that phosphorylation at Tyr-15 is not an activation mechanism of Cdk5 but, rather, indicate that tyrosine kinases could activate C DK5 by increasing the protein amount of p35, which is an important signaling cascade in a variety of neuronal activities.
The roles of cyclin‐dependent kinase 5 in dendrite and synapse development
TLDR
The existing knowledge on the pathways and mechanisms through which Cdk5 affects dendrite, synapse and spine development are summarized.
Abl Tyrosine Kinase Promotes Dendrogenesis by Inducing Actin Cytoskeletal Rearrangements in Cooperation with Rho Family Small GTPases in Hippocampal Neurons
TLDR
A critical role for Abl kinases in regulating dendrogenesis by inducing actin cytoskeletal rearrangements in cooperation with Rho GTPases is supported.
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It is shown that both cdk5 and p35 proteins are present in the growth cones of developing neurons, suggesting a function of cdk4 in neuronal differentiation and a critical role in neurite outgrowth during neuronal differentiation.
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Three distinct regions in p35 are identified required for binding to Cdk5 or activation of Cdk 5 in vitro, and residues ∼279-291 were needed in addition for activation ofCdk5 in vitro.
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