Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth

@article{Zukerberg2000CablesLC,
  title={Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth},
  author={Lawrence R. Zukerberg and Gentry N Patrick and Margareta Nikoli{\'c} and Sandrine Humbert and Chin-Lee Wu and Lorene M. Lanier and Frank B. Gertler and Marc Vidal and Richard A. Van Etten and Li-Huei Tsai},
  journal={Neuron},
  year={2000},
  volume={26},
  pages={633-646}
}
Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a substrate of the c-Abl tyrosine kinase. Active c-Abl kinase leads to Cdk5 tyrosine phosphorylation, and this phosphorylation is enhanced by Cables. Phosphorylation of Cdk5 by c-Abl occurs on tyrosine 15 (Y15), which is stimulatory for p35/Cdk5 kinase activity. Expression of… 
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The roles of cyclin‐dependent kinase 5 in dendrite and synapse development
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The existing knowledge on the pathways and mechanisms through which Cdk5 affects dendrite, synapse and spine development are summarized.
Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C.
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The results suggest that PKC exerts its effects on the phosphorylation state of Cdk5 substrates through an indirect mechanism that may involve the regulatory binding partners of Ckk5 other than its neuronal cofactors.
Abl Tyrosine Kinase Promotes Dendrogenesis by Inducing Actin Cytoskeletal Rearrangements in Cooperation with Rho Family Small GTPases in Hippocampal Neurons
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A critical role for Abl kinases in regulating dendrogenesis by inducing actin cytoskeletal rearrangements in cooperation with Rho GTPases is supported.
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