Cabergoline reduces cell viability in non functioning pituitary adenomas by inhibiting vascular endothelial growth factor secretion

@article{Gagliano2012CabergolineRC,
  title={Cabergoline reduces cell viability in non functioning pituitary adenomas by inhibiting vascular endothelial growth factor secretion},
  author={Teresa Gagliano and Carlo Filieri and Mariella Minoia and Mattia Buratto and Federico Tagliati and Maria Rosaria Ambrosio and Marcello Lapparelli and Matteo Zoli and Giorgio Frank and Ettore C. degli Uberti and Maria Chiara Zatelli},
  journal={Pituitary},
  year={2012},
  volume={16},
  pages={91-100}
}
Dopamine (DA) therapy of non-functioning pituitary adenomas (NFA) can result in tumor stabilization and shrinkage. However, the mechanism of action is still unknown. Previous evidence showed that DA can inhibit pituitary vascular endothelial growth factor expression (VEGF), that may be involved in pituitary tumor growth. The aim of our study was to clarify whether VEGF secretion modulation might mediate the effects of DA agonists on cell proliferation in human NFA. We assessed DA receptor… CONTINUE READING