Cabergoline prevents necrotic neuronal death in an in vitro model of oxidative stress.

@article{Lombardi2002CabergolinePN,
  title={Cabergoline prevents necrotic neuronal death in an in vitro model of oxidative stress.},
  author={Grazia Lombardi and Federica Varsaldi and Gianluca Miglio and Maria Grazia Papini and Angelo Battaglia and Pier Luigi Canonico},
  journal={European journal of pharmacology},
  year={2002},
  volume={457 2-3},
  pages={95-8}
}
To study if cabergoline, a long-lasting specific dopamine D2 receptor agonist, has neuroprotective effects against oxidative stress, we exposed (3 h) SH-SY5Y human neuroblastoma cells to tert-butylhydroperoxide (t-BOOH; 500 microM). t-BOOH caused a 42+/-4% neuronal death, which was prevented by cabergoline (2 h before) in a concentration-dependent manner (EC(50): 1.24 microM). This effect was not antagonised by haloperidol (concentration up to 10 microM), and was associated with an increased… CONTINUE READING