Cabazitaxel overcomes cisplatin resistance in germ cell tumour cells

@article{Gerwing2016CabazitaxelOC,
  title={Cabazitaxel overcomes cisplatin resistance in germ cell tumour cells},
  author={Mirjam Gerwing and Christine Jacobsen and Sergey A Dyshlovoy and Jessica Hauschild and Tina Rohlfing and Christoph Oing and Simone Venz and Jan Oldenburg and Karin Oechsle and C Carsten Bokemeyer and Gunhild von Amsberg and Friedemann Honecker},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2016},
  volume={142},
  pages={1979-1994}
}
Cisplatin-based chemotherapy is highly effective in metastasized germ cell tumours (GCT). However, 10–30 % of patients develop resistance to cisplatin, requiring salvage therapy. We investigated the in vitro activity of paclitaxel and the novel taxane cabazitaxel in cisplatin-sensitive and -resistant GCT cell lines. In vitro activity of paclitaxel and cabazitaxel was determined by proliferation assays, and mode of action of cabazitaxel was assessed by western blotting and two screening… CONTINUE READING