CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses.

@article{Zhang2007CaMKIIdeltaID,
  title={CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses.},
  author={Tong Zhang and Michael Kohlhaas and Johannes Backs and Shikha Mishra and William O. Phillips and Nataliya Dybkova and Shurong Chang and Haiyun Ling and Donald M. Bers and Lars Siegfried Maier and Eric N Olson and Joan Brown},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 48},
  pages={35078-87}
}
The delta(B) and delta(C) splice variants of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), which differ by the presence of a nuclear localization sequence, are both expressed in cardiomyocytes. We used transgenic (TG) mice and CaMKII expression in cardiomyocytes to test the hypothesis that the CaMKIIdelta(C) isoform regulates cytosolic Ca(2+) handling and the delta(B) isoform, which localizes to the nucleus, regulates gene transcription. Phosphorylation of CaMKII sites on the… CONTINUE READING
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