CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function.

@article{Guo2010CaMKIIalphaIW,
  title={CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function.},
  author={Ming-Lei Guo and Eugene E. Fibuch and X Liu and Eun Sang Choe and Shilpa Buch and Li-min Mao and John Q Wang},
  journal={The EMBO journal},
  year={2010},
  volume={29 12},
  pages={2070-81}
}
Muscarinic acetylcholine receptors (mAChRs) are widely expressed in the mammalian brain and are essential for neuronal functions. These receptors are believed to be actively regulated by intracellular signals, although the underlying mechanisms are largely unknown. In this study, we show that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) binds directly and selectively to one of five mAChR subtypes, M4 receptors (M4Rs), at their C-terminal regions of second intracellular loops. This… CONTINUE READING